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KMID : 0363220120500121027
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Korean Journal of Dermatology
2012 Volume.50 No. 12 p.1027 ~ p.1035
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Linear Hyperpigmentation Along the Blaschko’s Line: A Clinicopathologic Study
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Kim Hyung-Ok
Kim Eun-Kyung
Jung Kyung-Eun
Kim Hei-Sung
Lee Jun-Young
Park Young-Min
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Abstract
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Background: Many pigmentary disorders can be manifested as linear streaks of hyperpigmentation, along theBlaschko`s line. These include progressive cribriform and zosteriform hyperpigmentation (PCZH) and linear andwhorled nevoid hyperpigmentation (LWNH). There have been debates on the universally accepted diagnostic criteriadifferentiating these disease entities.Objective: To determine the clinicopathologic characteristics of hyperpigmentation along the line of Blaschko and toexamine the acceptability of PCZH or LWNH criteria as a diagnostic tool for differentiating these diseases.Methods: A retrospective study was conducted on 13 patients who presented with linear hyperpigmentation alongthe Blaschko`s line. The patients` clinicopathologic characteristics were analyzed and matched with the PCZH/LWNH diagnostic criteria.Results: Age of onset widely ranged from birth to 61 years, but predominantly before the age of 4 years. Themale-female ratio was 1：1.2. Trunk was the most common site of involvement. Histologic examination commonlyshowed a basal layer hyperpigmentation in all patients and pigmentary incontinence was observed in 2 patients. Fourpatients who satisfied all the diagnostic criteria for PCZH also fulfilled the diagnostic criteria for LWNH, except forthe timing of onset. An additional 4 patients satisfied all the diagnostic criteria for LWNH and also fulfilled thediagnostic criteria for PCZH, except for the timing of onset. Excluding the age of onset criteria, the other 3 patientsfulfilled both diagnostic criteria for PCZH and LWNH.Conclusion: These results demonstrate that PCZH and LWNH should not be considered as a different disease entityand that supports the idea that these are part of the same disease spectrum.
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KEYWORD
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Blaschko`s Line, Hyperpigmentation, Linear and whorled nevoid hyperpigmentation, Progressive cribriform and zosteriform hyperpigmentation
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